DhrR
29-12-2004, 16:55
Metalsa berbers zijn verwant met chaouya arabieren in west marokko (en in mindere mate met spanjaarden, fransen en etiopiers) volgens een DNA onderzoek van Laboratoire d'Immunologie, Institut National D'Hygiene, Rabat, Morocco.
Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco.
Oumhani K, Canossi A, Piancatelli D, Di Rocco M, Del Beato T, Liberatore G, Aureli A, Benjoaud A, El Aouad R, Adorno D, Casciani CU.
Laboratoire d'Immunologie, Institut National D'Hygiene, Rabat, Morocco.
To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlantic coast) living in the Settat area. The DRB1 alleles of 197 healthy unrelated individuals were identified by direct DNA sequencing of exon 2 using fluorescently-labeled primers. A total of 28 and 29 alleles at DRB1 locus were identified in the Metalsa and Chaouya groups, respectively. The most frequent alleles in the Metalsa group are DRB1x03011 (20.2%), DRB1x0701 (12.12%), and DRB1x1302 (11.11%). In the Chaouya group, DRB1x0701 (16.33%), DRB1x15011 (12.76%), and DRB1x03011 (11.73%) are most common. Each population exhibits some specific variants and some uncommon alleles. The frequency of the DRB1x03011 allele differs significantly between the two populations (p = 0.0311). The DRB1 frequency distributions in the two groups suggest the effects of balancing selection. The interpopulation analysis highlighted a strong relatedness, based on genetic distances, between the two Moroccan groups and the other north Africans (the Moroccans from El Jadida area, Moroccan Souss Berbers, Algerians, and Tunisians), and to a lesser extent with the Iberians, French, and Ethiopians.
PMID: 11821160 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=118211 60&dopt=Abstract
Sequence-Based analysis of the HLA-DRB1 polymorphism in Metalsa Berber and Chaouya Arabic-speaking groups from Morocco.
Oumhani K, Canossi A, Piancatelli D, Di Rocco M, Del Beato T, Liberatore G, Aureli A, Benjoaud A, El Aouad R, Adorno D, Casciani CU.
Laboratoire d'Immunologie, Institut National D'Hygiene, Rabat, Morocco.
To examine the genetic diversity in Morocco, the polymorphism at the HLA-DRB1 locus was investigated in two populations: the Metalsa group consisting of Berbers from north Morocco (who speak the Tarifit language and live in the Nador area), and the Chaouya group who are Arabic-speaking people from west Morocco (Atlantic coast) living in the Settat area. The DRB1 alleles of 197 healthy unrelated individuals were identified by direct DNA sequencing of exon 2 using fluorescently-labeled primers. A total of 28 and 29 alleles at DRB1 locus were identified in the Metalsa and Chaouya groups, respectively. The most frequent alleles in the Metalsa group are DRB1x03011 (20.2%), DRB1x0701 (12.12%), and DRB1x1302 (11.11%). In the Chaouya group, DRB1x0701 (16.33%), DRB1x15011 (12.76%), and DRB1x03011 (11.73%) are most common. Each population exhibits some specific variants and some uncommon alleles. The frequency of the DRB1x03011 allele differs significantly between the two populations (p = 0.0311). The DRB1 frequency distributions in the two groups suggest the effects of balancing selection. The interpopulation analysis highlighted a strong relatedness, based on genetic distances, between the two Moroccan groups and the other north Africans (the Moroccans from El Jadida area, Moroccan Souss Berbers, Algerians, and Tunisians), and to a lesser extent with the Iberians, French, and Ethiopians.
PMID: 11821160 [PubMed - indexed for MEDLINE]
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=118211 60&dopt=Abstract